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Death Receptor Signaling
| Alternative Name | APO-1L, CD95L, CD178, TNFSF 6 |
|---|---|
| Purity | ≥95% (SDS-PAGE) |
| Source | Produced in HEK 293 cells. The extracellular domain of human FasL (APO-1L; CD95L; CD178) (aa 103-281) is fused at the N-terminus to a linker peptide (26 aa) and a FLAG®-tag. Glycosylation of rhsFasL is similar to that of natural human FasL. |
| Alternative Name | CD95L, APO-1L, CD178, TNFSF 6 |
|---|---|
| Application | Flow Cytometry, FUNC |
| Host | Mouse |
| Isotype | IgG1 |
| Species Reactivity | Human, Mouse |
| Alternative Name | CASPER, CLARP, I-FLICE, Usurpin, CFLAR |
|---|---|
| Application | ELISA, Flow Cytometry, IHC, WB |
| Host | Mouse |
| Isotype | IgG1 |
| Species Reactivity | Human |
KillerTRAIL™ Protein (soluble) (human), (recombinant)
ALX-201-073
Enhanced ligand that utilizes the proprietary Killer™ linker peptide that promotes stability.
| Alternative Name | Apo-2L, TNFSF 10, CD253 |
|---|---|
| Purity | ≥99% (SDS-PAGE, MS analysis) |
| Source | Produced in E. coli. The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a His-tag and a linker peptide. |
| Alternative Name | Apo-2L, TNFSF 10, CD253 |
|---|---|
| Purity | ≥98% (SDS-PAGE) |
| Source | Produced in E. coli. The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a His-tag and a linker peptide. |
| Application | IHC (PS), WB |
|---|---|
| Host | Mouse |
| Isotype | IgG1 |
| Species Reactivity | Human, Mouse |
| Alternative Name | CRADD, Caspase and RIP adaptor with death domain, RIP-associated protein with a death domain |
|---|---|
| Application | IP, WB |
| Host | Rabbit |
| Species Reactivity | Human |
SUPERFASLIGAND® Protein (soluble) (human), (recombinant)
ALX-522-020
Fas ligand with improved stability providing significantly enhanced immune activation.
| Alternative Name | FasL (oligomer), APO-1L (oligomer), CD95L (oligomer), CD178 (oligomer), TNFSF 6 (oligomer) |
|---|---|
| Purity | ≥95% (SDS-PAGE) |
| Source | Produced in HEK 293 cells. The extracellular domain of human FasL (APO-1L; CD95L; CD178) (aa 103-281) is fused at the N-terminus to a linker peptide (26 aa) and a FLAG®-tag. Glycosylation of rhs SUPERFASLIGAND® is similar to natural human FasL. |
SUPERKILLERTRAIL® Protein (soluble) (human), (recombinant)
ALX-201-115
Enhanced ligand with improved stability providing significantly enhanced immune activation.
| Alternative Name | TNFSF 10, Apo-2L, CD253 |
|---|---|
| Purity | ≥98% (SDS-PAGE). MS analysis, <1% impurity (mainly Hsp70 protein from E. coli) |
| Source | Produced in E. coli. The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a His-tag and a linker peptide. The active multimeric conformation is stabilized by an inserted mutation allowing an additional CC-bridge. |
| Alternative Name | Apo-2L, TNFSF 10, CD253 |
|---|---|
| Application | Flow Cytometry, FUNC |
| Host | Mouse |
| Isotype | IgG1 |
| Species Reactivity | Human |
| Alternative Name | Apo-2L, TNFSF 10, CD253 |
|---|---|
| Application | ELISA, Flow Cytometry, IHC (FS), IP, WB |
| Host | Mouse |
| Isotype | IgG2b |
| Species Reactivity | Human |
| Alternative Name | Apo-2L, TNFSF 10, CD253 |
|---|---|
| Application | Flow Cytometry |
| Host | Mouse |
| Isotype | IgG1 |
| Species Reactivity | Human |
| Alternative Name | Apo-2L, TNFSF 10, CD253 |
|---|---|
| Application | Flow Cytometry, ICC, IHC (FS), WB |
| Host | Rabbit |
| Species Reactivity | Human |