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Apoptosis Signaling
| Alternative Name | 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiophene-2-carboxamide |
|---|---|
| CAS | 912545-86-9 |
| Couple Type | Activator, Ligand |
| Purity | ≥95% (HPLC) |
| Alternative Name | Pseudochelerythrine |
|---|---|
| CAS | 5578-73-4 |
| Couple Type | Inhibitor |
| Purity | ≥98% (HPLC) |
| Alternative Name | Shh signaling antagonist V, (E)-N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenylpyrazol-4-yl)methanimine |
|---|---|
| CAS | 304909-07-7 |
| Couple Type | Inhibitor |
| Purity | ≥99% (HPLC) |
| Alternative Name | N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide |
|---|---|
| CAS | 329196-48-7 |
| Couple Type | Inhibitor |
| Purity | ≥95% |
| Alternative Name | Second mitochondria-derived activator of caspase |
|---|---|
| Application | IHC (PS), WB |
| Host | Mouse |
| Isotype | IgG2b |
| Species Reactivity | Human, Monkey |
| CAS | 327033-36-3 |
|---|---|
| Couple Type | Inhibitor |
| Purity | ≥95% (HPLC, TLC, NMR/ELSD) |
| Alternative Name | LDE225 (free base) |
|---|---|
| CAS | 956697-53-3 |
| Couple Type | Inhibitor |
| Purity | ≥99% (HPLC) |
SUPERFASLIGAND® Protein (soluble) (human), (recombinant)
ALX-522-020
Fas ligand with improved stability providing significantly enhanced immune activation.
| Alternative Name | FasL (oligomer), APO-1L (oligomer), CD95L (oligomer), CD178 (oligomer), TNFSF 6 (oligomer) |
|---|---|
| Purity | ≥95% (SDS-PAGE) |
| Source | Produced in HEK 293 cells. The extracellular domain of human FasL (APO-1L; CD95L; CD178) (aa 103-281) is fused at the N-terminus to a linker peptide (26 aa) and a FLAG®-tag. Glycosylation of rhs SUPERFASLIGAND® is similar to natural human FasL. |
SUPERKILLERTRAIL® Protein (soluble) (human), (recombinant)
ALX-201-115
Enhanced ligand with improved stability providing significantly enhanced immune activation.
| Alternative Name | TNFSF 10, Apo-2L, CD253 |
|---|---|
| Purity | ≥98% (SDS-PAGE). MS analysis, <1% impurity (mainly Hsp70 protein from E. coli) |
| Source | Produced in E. coli. The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a His-tag and a linker peptide. The active multimeric conformation is stabilized by an inserted mutation allowing an additional CC-bridge. |
| Alternative Name | BIRC5, EPR1 |
|---|---|
| Application | IHC, WB |
| Host | Mouse |
| Isotype | IgG2a |
| Species Reactivity | Human, Mouse, Rat |
| Alternative Name | Transmembrane activator and CAML interactor, TNFRSF 13B, CD267 |
|---|---|
| Application | Flow Cytometry |
| Host | Rat |
| Isotype | IgG2a |
| Species Reactivity | Mouse |
| Alternative Name | TNFRSF 13B, Transmembrane activator and CAML interactor, CD267 |
|---|---|
| Application | ICC, WB |
| Host | Rabbit |
| Species Reactivity | Human |
