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IDH1 (Isocitrate Dehydrogenase 1) is an enzyme found in the cytoplasm and perixosomes. IDH1 is a metabolic gene that is often mutated in human cancer. It is involved in metabolic and cellular pathways, specifically the Krebs cycle. Mutations are frequently found in diffuse low-grade gliomas and secondary glioblastomas, but rarely in primary glioblastomas. The most notable mutation in this enzyme is replacing amino acid arginine with histidine at codon 132 (R132H).
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Formalin-fixed paraffin-embedded glioblastoma tissue stained using Enzo’s IDH1 antibody (Prod. No. ENZ-ABS774). IHC staining was performed on an automated Leica BOND III.
| Regulatory Status |
RUO – Research Use Only |
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ADI-950-261
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