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Monensin . sodium salt

ALX-380-026

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Na⁺ ionophore

Antibiotic that functions as Na⁺ ionophore. Blocks glycoprotein secretion. Inhibits proliferation of several lymphoma cell lines through cell cycle arrest and apoptosis. Blocks ceramide transport through the Golgi apparatus.

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Product Details

Appearance	White to light yellow powder.
CAS	22373-78-0
Formula	C₃₆H₆₁O₁₁ . Na
MI	14: 6246
MW	669.9 . 23.0
Purity	≥90%
Solubility	Soluble in 100% ethanol (25mg/ml), methanol (50mg/ml), chloroform or DMSO (25mg/ml). Slightly soluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Store tightly sealed in the dark.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A purinergic mechanism underlying metformin regulation of hyperglycemia: Senfeld, J., Peng, Q., et al.; iScience 26, 106898 (2023), Abstract
Increased Th9 cells and IL-9 levels accelerate disease progression in experimental atherosclerosis: Q. Li, et al.; Am. J. Transl. Res. 9, 1335 (2017), Abstract — Full Text
Image-based drug screen identifies HDAC inhibitors as novel Golgi disruptors synergizing with JQ1: M. Gendarme, et al.; Mol. Biol. Cell. 28, 3756 (2017), Abstract — Full Text
Elevated Th22 cells and related cytokines in patients with epithelial ovarian cancer: T. Wang, et al.; Medicine (Baltimore) 96, e8359 (2017), Application(s): Flow Cytometry, Abstract — Full Text
Interleukin-37 and Dendritic Cells Treated With Interleukin-37 Plus Troponin I Ameliorate Cardiac Remodeling After Myocardial Infarction: R. Zhu, et al.; J. Am. Heart Assoc. 5, e004406 (2016), Abstract — Full Text
Olfactory ecto-mesenchymal stem cells possess immunoregulatory function and suppress autoimmune arthritis: K. Rui, et al.; Cell. Mol. Immunol. 13, 401 (2015), Application(s): Flow cytometric analysis in mouse cells, Abstract
The Profile of T Helper Subsets in Bone Marrow Microenvironment Is Distinct for Different Stages of Acute Myeloid Leukemia Patients and Chemotherapy Partly Ameliorates These Variations: T. Tian, et al.; PLoS One 10, e0131761 (2015), Application(s): Cell Culture, Abstract — Full Text
Inactivation of Notch signaling reverses the Th17/Treg imbalance in cells from patients with immune thrombocytopenia: Yu, S., Liu, C., et al.; Lab. Invest. 95, 157 (2015), Abstract
Monensin-mediated growth inhibition in human lymphoma cells through cell cycle arrest and apoptosis: W. H. Park, et al.; Br. J. Haematol. 119, 400 (2002), Abstract
Sphingomyelin transport to the cell surface occurs independently of protein secretion in rat hepatocytes: Y.J. Shiao & J.E. Vance; J. Biol. Chem. 268, 26085 (1993), Abstract

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Last modified: May 29, 2024

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Monensin . sodium salt

ALX-380-026

Product Details

Handling & Storage

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