Home Shop Monophosphoryl Lipid A from Salmonella minnesota R595 (Re) (TLRGRADE®) (Ready-to-Use)

Monophosphoryl Lipid A from Salmonella minnesota R595 (Re) (TLRGRADE®) (Ready-to-Use)

ALX-581-202

6 citations

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TLR4 activator

Adjuvant

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Product Details

Activity	Activates Toll-like receptor (TLR) 4. Does not activate TLR2 as determined with splenocytes and macrophages from TLR4 deficient mice. Exhibits reduced endotoxic and pyrogenic activity compared to lipid A and LPS.
Alternative Name	MPL-A from Salmonella minnesota R595 (Re)
Couple Target	TLR, TLR4
Couple Type	Activator, Ligand
Formulation	Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.
Purity	≥99.9% (regarding protein or DNA contaminants; KDO not detectable)
Source	Isolated from Salmonella minnesota R595 (Re mutant). Prepared by acid hydrolysis from purified Salmonella minnesota R595 (Re) LPS (isolated by a modification of the PCP extraction method), converted to the uniform salt form and dissolved in sterile pyrogen-free double distilled water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Keep sterile.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

MPL Adjuvant Contains Competitive Antagonists of Human TLR4: Y.Q. Wang, et al.; Front. Immunol. 11, 577823 (2020), Abstract — Full Text
Specific features of human monocytes activation by monophosphoryl lipid A: R. Chentouh, et al.; Sci. Rep. 8, 7096 (2018), Abstract — Full Text
CD14 and TRIF govern distinct responsiveness and responses in mouse microglial TLR4 challenges by structural variants of LPS: T. Regen, et al.; Brain Behav. Immun. 25, 957 (2011), Abstract
Isolation and purification of R-form lipopolysaccharides: C. Galanos & O. Luderitz; Meth. Carbohydr. Chem. 9, 11 (1993)
Electrodialysis of lipopolysaccharides and their conversion to uniform salt forms: C. Galanos & O. Luderitz; Eur. J. Biochem. 54, 603 (1975), Abstract
A new method for the extraction of R lipopolysaccharides: C. Galanos, et al.; Eur. J. Biochem. 9, 245 (1969), Abstract

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Monophosphoryl Lipid A from Salmonella minnesota R595 (Re) (TLRGRADE®) (Ready-to-Use)

ALX-581-202

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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