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ENZO Biochem Says Lawsuit Filed Against Affymetrix for Breach of Agreement

FARMINGDALE, NY, October 28, 2003 – Enzo Biochem, Inc. (NYSE:ENZ) announced today that its subsidiary, Enzo Life Sciences, Inc. (“Enzo”) has terminated its agreement with Affymetrix, Inc. (“Affymetrix”) and filed a lawsuit against Affymetrix in the U.S. District Court for the Eastern District of New York.  The Complaint charges that Affymetrix breached its agreement with Enzo by, among other things, misappropriating Enzo assets, and manufacturing and selling Enzo products in violation of the terms of the agreement.  The lawsuit was filed, Enzo said, after unsuccessful lengthy negotiations to resolve these and other issues.
 
In the Complaint, Enzo alleges that Affymetrix improperly transferred or distributed substantial business assets of Enzo to third parties, including portions of the Company’s proprietary technology, instruments, reagent systems, detection reagents and other intellectual property.  The Complaint also charges that Affymetrix failed to account for certain shortfalls in sales of Enzo’s products or to reimburse Enzo for unauthorized manufacturing and sale of its products, and that Affymetrix improperly induced collaborators and customers to use Enzo products in unauthorized fields or otherwise in violation of the agreement.
 
The Complaint seeks full compensation from Affymetrix to Enzo for its substantial damages, in addition to injunctive and declaratory relief to prohibit, among other things, Affymetrix’s unauthorized use, development, manufacture, sale, distribution and transfer of Enzo’s products, technology, and/or intellectual property, as well as to prohibit Affymetrix from inducing collaborators, joint venture partners, customers and other third parties to use Enzo products in violation of the terms of the agreement and Enzo’s rights. 
 
About Enzo
Enzo Biochem is engaged in the research, development and manufacture of innovative health care products based on molecular biology and genetic engineering techniques, and in providing diagnostic services to the medical community.  The Company's proprietary labeling and detection products for gene sequencing and genetic analysis, with approximately 200 patents worldwide, are sold to the life sciences market throughout the world.  The Company's therapeutic division is in various stages of clinical evaluation of its proprietary gene medicine for HIV-1 infection and its proprietary immune regulation medicines for hepatitis B and hepatitis C infection and for Crohn’s Disease.  The Company also holds a patent covering a method and materials for correcting point mutations or small insertions or deletions of genetic material that would allow for editing and correcting certain abnormalities in genes.  For more information visit our website www.enzo.com.  

Except for historical information, the matters discussed in this news release may be considered ”forward‑looking" statements within the meaning of Section 27A of the Securities Act of 1933, as amended and Section 21E of the Securities Exchange Act of 1934, as amended.  Such statements include declarations regarding the intent, belief or current expectations of the Company and its management. Investors are cautioned that any such forward‑looking statements are not guarantees of future performance and involve a number of risks and uncertainties that could materially affect actual results.  The Company disclaims any obligations to update any forward-looking statement as a result of developments occurring after the date of this press release.
 
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