Continues to Explore Opportunities for Use of the Compound as a Potential Treatment for COVID-19
NEW YORK, NY, June 23, 2020 -- Enzo Biochem, Inc. (NYSE: ENZ), a leading biosciences and diagnostics company, today announced it has received a patent for the treatment of liver cancer, U.S. Patent No. 10,675,255 entitled Sphingosine Pathway Modulating Compounds for the Treatment of Cancers. Enzo’s patent is directed to methods for treating hepatocellular carcinoma (HCC), the most common human liver cancer, using the company’s proprietary compound SK1-I and has a term extending into June 2038. Foreign patent applications in the same patent family are currently pending.
Elazar Rabbani, Ph.D., CEO of Enzo Biochem, Inc. commented: “This new application of our proprietary compound is an important step in our program to advance SK1-I as a potential treatment for liver cancer and other cancers. Both our internal studies and the work of others have shown that SK1-I can not only inhibit the growth of various types of cancer cells but can also modulate the activity of immune cells. Given this, we also continue to explore avenues for developing SK1-I as a potential treatment for COVID-19, the disease caused by the novel coronavirus SARS-Cov-2.”
Sphingosine kinase 1 is a key enzyme in the Sphingosine cell-signaling pathway that has been implicated in tumor cell growth and pathological inflammation. The enzyme acts by phosphorylating the cellular lipid Sphingosine to form Sphingosine 1-Phosphate (S1P), an important biological mediator of cell proliferation and immune function. SK1-I is a small molecule that specifically inhibits Sphingosine kinase 1.
HCC represents more than 90% of primary human liver cancers and a significant unmet medical need in the United States and globally. In the U.S., the incidence of liver cancer has been rising for many years with 33,000 new cases annually and 27,000 deaths from the disease. Currently, about 26% of liver cancer patients will live five years after diagnosis if the cancer has not spread beyond the liver, but only 4% will live as long if the cancer has spread from the liver to other parts of the body.About Enzo Biochem
Enzo Biochem is a pioneer in molecular diagnostics, leading the convergence of clinical laboratories, life sciences and intellectual property through the development of unique diagnostic platform technologies that provide numerous advantages over previous standards. A global company, Enzo Biochem utilizes cross-functional teams to develop and deploy products, systems and services that meet the ever-changing and rapidly growing needs of health care today and into the future. Underpinning Enzo Biochem’s products and technologies is a broad and deep intellectual property portfolio, with patent coverage across a number of key enabling technologies.
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